Drug interactions
Griseofulvin + Itraconazole
Severity: Moderate
Griseofulvin and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a CYP3A4 inducer that may lower itraconazole concentrations. The two are both antifungals with overlapping uses, so combining them is rarely justified.
What this interaction means in plain words
Griseofulvin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Itraconazole belongs to Anti Fungals.
Why it happens
Griseofulvin induces CYP3A4, increasing itraconazole metabolism.
What to do
Avoid the combination where possible; if needed, monitor clinical response and itraconazole levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Itraconazole?
MediHelp rates the interaction as moderate. Griseofulvin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin is a CYP3A4 inducer that may lower itraconazole concentrations. The two are both antifungals with overlapping uses, so combining them is rarely justified.
How serious is the interaction between Griseofulvin and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, monitor clinical response and itraconazole levels.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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