Drug interactions
Griseofulvin + Midazolam
Severity: Moderate
Griseofulvin and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may reduce midazolam concentrations, particularly with oral dosing, leading to diminished sedation or anxiolysis. The effect resolves slowly after the inducer is stopped.
What this interaction means in plain words
Griseofulvin and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Midazolam belongs to Central Nervous System.
Why it happens
Induction of intestinal and hepatic CYP3A4 increases midazolam first-pass metabolism.
What to do
Monitor sedation response and titrate midazolam dose upward as needed. Watch for excess sedation after griseofulvin is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Griseofulvin with Midazolam?
MediHelp rates the interaction as moderate. Griseofulvin and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may reduce midazolam concentrations, particularly with oral dosing, leading to diminished sedation or anxiolysis. The effect resolves slowly after the inducer is stopped.
How serious is the interaction between Griseofulvin and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation response and titrate midazolam dose upward as needed. Watch for excess sedation after griseofulvin is discontinued.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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