Drug interactions
Guanfacine + Loxapine
Severity: Moderate
Guanfacine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure and cause sedation. Together they may increase hypotension, dizziness, syncope and drowsiness.
What this interaction means in plain words
Guanfacine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guanfacine belongs to Cardiovascular; Loxapine belongs to Central Nervous System.
Why it happens
Additive hypotensive effect from central alpha-2 agonism and alpha-adrenergic blockade by loxapine, plus additive sedation.
What to do
Monitor blood pressure and heart rate, especially on initiation and dose increases, and counsel patients to rise slowly. Reduce doses if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Guanfacine with Loxapine?
MediHelp rates the interaction as moderate. Guanfacine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure and cause sedation. Together they may increase hypotension, dizziness, syncope and drowsiness.
How serious is the interaction between Guanfacine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially on initiation and dose increases, and counsel patients to rise slowly. Reduce doses if orthostatic symptoms occur.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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