Drug interactions
Guanfacine + Maprotiline
Severity: Moderate
Guanfacine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline may blunt the blood pressure lowering effect of guanfacine, leading to loss of blood pressure control. The effect is described mainly with tricyclic antidepressants.
What this interaction means in plain words
Guanfacine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guanfacine belongs to Cardiovascular; Maprotiline belongs to Central Nervous System.
Why it happens
Maprotiline blocks neuronal uptake and may oppose the central alpha-2 agonist effect of guanfacine; mechanism not fully established.
What to do
Monitor blood pressure after starting or changing maprotiline, and adjust guanfacine or use another antihypertensive if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Guanfacine with Maprotiline?
MediHelp rates the interaction as moderate. Guanfacine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline may blunt the blood pressure lowering effect of guanfacine, leading to loss of blood pressure control. The effect is described mainly with tricyclic antidepressants.
How serious is the interaction between Guanfacine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or changing maprotiline, and adjust guanfacine or use another antihypertensive if control is lost.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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