Drug interactions
Guanfacine + Mifepristone
Severity: Moderate
Guanfacine and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Guanfacine is metabolized mainly by CYP3A4, and strong inhibitors increase its exposure. This can cause hypotension, bradycardia and sedation.
What this interaction means in plain words
Guanfacine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guanfacine belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4, reducing guanfacine clearance.
What to do
Consider reducing the guanfacine dose and monitor blood pressure, heart rate and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Guanfacine with Mifepristone?
MediHelp rates the interaction as moderate. Guanfacine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Guanfacine is metabolized mainly by CYP3A4, and strong inhibitors increase its exposure. This can cause hypotension, bradycardia and sedation.
How serious is the interaction between Guanfacine and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the guanfacine dose and monitor blood pressure, heart rate and sedation.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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