Drug interactions
Guanfacine + Tolazamide
Severity: Minor
Guanfacine and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Guanfacine, a central alpha-2 agonist, may blunt the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations. Patients on tolazamide may therefore fail to recognise low glucose early.
What this interaction means in plain words
Guanfacine and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Guanfacine belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
Reduced sympathetic catecholamine response to hypoglycemia through central alpha-2 agonism.
What to do
Advise patients to monitor blood glucose regularly rather than rely on symptoms. Remind them that sweating is usually preserved.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Guanfacine with Tolazamide?
MediHelp rates the interaction as minor. Guanfacine and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Guanfacine, a central alpha-2 agonist, may blunt the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations. Patients on tolazamide may therefore fail to recognise low glucose early.
How serious is the interaction between Guanfacine and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor blood glucose regularly rather than rely on symptoms. Remind them that sweating is usually preserved.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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