Drug interactions
Guselkumab + Rozanolixizumab
Severity: Moderate
Guselkumab and Rozanolixizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rozanolixizumab blocks the neonatal Fc receptor, which normally recycles IgG antibodies and prolongs their half-life. Guselkumab is an IgG monoclonal antibody, so its exposure could be reduced and efficacy lessened.
What this interaction means in plain words
Guselkumab and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guselkumab belongs to Miscellaneous; Rozanolixizumab belongs to Miscellaneous.
Why it happens
FcRn blockade increases IgG catabolism, which may lower guselkumab concentrations.
What to do
Monitor for loss of guselkumab efficacy during and after rozanolixizumab cycles. Consider alternative therapy if long-term guselkumab response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Other interactions of Rozanolixizumab
- Rozanolixizumab + Upadacitinib Major
- Abatacept + Rozanolixizumab Moderate
- Adalimumab + Rozanolixizumab Moderate
- Ado-trastuzumab + Rozanolixizumab Moderate
- Basiliximab + Rozanolixizumab Moderate
- Bevacizumab + Rozanolixizumab Moderate
Frequently asked questions
Can I take Guselkumab with Rozanolixizumab?
MediHelp rates the interaction as moderate. Guselkumab and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor, which normally recycles IgG antibodies and prolongs their half-life. Guselkumab is an IgG monoclonal antibody, so its exposure could be reduced and efficacy lessened.
How serious is the interaction between Guselkumab and Rozanolixizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of guselkumab efficacy during and after rozanolixizumab cycles. Consider alternative therapy if long-term guselkumab response is lost.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
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