Drug interactions
Guselkumab + Thioridazine
Severity: Minor
Guselkumab and Thioridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation can suppress CYP450 enzyme activity through raised cytokines, and effective IL-23 blockade may restore normal enzyme activity. This could modestly change levels of CYP substrates such as thioridazine. A clinically meaningful effect has not been shown for guselkumab.
What this interaction means in plain words
Guselkumab and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Guselkumab belongs to Miscellaneous; Thioridazine belongs to Central Nervous System.
Why it happens
Theoretical normalization of cytokine-suppressed CYP450 activity when inflammation is controlled.
What to do
No dose change is routinely needed. Monitor clinical response and ECG if thioridazine effect appears to change after guselkumab is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Guselkumab with Thioridazine?
MediHelp rates the interaction as minor. Guselkumab and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation can suppress CYP450 enzyme activity through raised cytokines, and effective IL-23 blockade may restore normal enzyme activity. This could modestly change levels of CYP substrates such as thioridazine. A clinically meaningful effect has not been shown for guselkumab.
How serious is the interaction between Guselkumab and Thioridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor clinical response and ECG if thioridazine effect appears to change after guselkumab is started or stopped.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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