Drug interactions
Haemophilus influenzae type b vaccine + Infliximab
Severity: Minor
Haemophilus influenzae type b vaccine and Infliximab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infliximab may reduce the immune response to the inactivated Hib vaccine. Protection may therefore be lower than expected, but the vaccine is safe to administer.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Infliximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
TNF-alpha inhibition blunts humoral response to vaccine antigens.
What to do
Vaccinate at least 2 weeks before starting infliximab where feasible. If given during therapy, consider whether revaccination is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Haemophilus influenzae type b vaccine and Infliximab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Infliximab?
MediHelp rates the interaction as minor. Haemophilus influenzae type b vaccine and Infliximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Infliximab may reduce the immune response to the inactivated Hib vaccine. Protection may therefore be lower than expected, but the vaccine is safe to administer.
How serious is the interaction between Haemophilus influenzae type b vaccine and Infliximab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting infliximab where feasible. If given during therapy, consider whether revaccination is needed.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
