Drug interactions
Haemophilus influenzae type b vaccine + Methylprednisolone
Severity: Moderate
Haemophilus influenzae type b vaccine and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of corticosteroids can reduce antibody responses to the conjugate vaccine. The patient may have inadequate protection after vaccination.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid immunosuppression blunts the vaccine-induced antibody response.
What to do
Vaccinate before starting immunosuppressive therapy when possible, or consider revaccination after the corticosteroid dose is reduced or stopped and immune function has recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Methylprednisolone?
MediHelp rates the interaction as moderate. Haemophilus influenzae type b vaccine and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppressive doses of corticosteroids can reduce antibody responses to the conjugate vaccine. The patient may have inadequate protection after vaccination.
How serious is the interaction between Haemophilus influenzae type b vaccine and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting immunosuppressive therapy when possible, or consider revaccination after the corticosteroid dose is reduced or stopped and immune function has recovered.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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