Drug interactions
Haloperidol + Imipramine
Severity: Major
Haloperidol and Imipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol inhibits CYP2D6 and may raise imipramine concentrations, while both drugs prolong the QT interval. Together they increase the risk of ventricular arrhythmias, and also of sedation and anticholinergic effects.
What this interaction means in plain words
Haloperidol and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by haloperidol combined with additive QT prolongation.
What to do
Check ECG and electrolytes before and during combined therapy, and consider lowering the imipramine dose guided by plasma levels. Prefer an antipsychotic with lower QT liability when possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Imipramine?
MediHelp rates the interaction as major. Haloperidol and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Haloperidol inhibits CYP2D6 and may raise imipramine concentrations, while both drugs prolong the QT interval. Together they increase the risk of ventricular arrhythmias, and also of sedation and anticholinergic effects.
How serious is the interaction between Haloperidol and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before and during combined therapy, and consider lowering the imipramine dose guided by plasma levels. Prefer an antipsychotic with lower QT liability when possible.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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