Drug interactions
Haloperidol + Isoflurane
Severity: Moderate
Haloperidol and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval, and haloperidol adds to this effect. This can increase perioperative arrhythmia risk, particularly with electrolyte disturbances.
What this interaction means in plain words
Haloperidol and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Check the baseline ECG and correct potassium and magnesium before surgery. Monitor the ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Haloperidol with Isoflurane?
MediHelp rates the interaction as moderate. Haloperidol and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval, and haloperidol adds to this effect. This can increase perioperative arrhythmia risk, particularly with electrolyte disturbances.
How serious is the interaction between Haloperidol and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline ECG and correct potassium and magnesium before surgery. Monitor the ECG during anesthesia.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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