Drug interactions
Haloperidol + Istradefylline
Severity: Minor
Haloperidol and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at the higher 40 mg daily dose weakly inhibits CYP3A4 and can raise levels of sensitive substrates such as haloperidol. Higher haloperidol exposure may increase sedation, extrapyramidal symptoms and QT effects.
What this interaction means in plain words
Haloperidol and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by istradefylline at higher doses reducing haloperidol clearance.
What to do
Monitor for increased haloperidol adverse effects and consider a dose reduction if they appear, particularly when istradefylline 40 mg daily is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Haloperidol with Istradefylline?
MediHelp rates the interaction as minor. Haloperidol and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at the higher 40 mg daily dose weakly inhibits CYP3A4 and can raise levels of sensitive substrates such as haloperidol. Higher haloperidol exposure may increase sedation, extrapyramidal symptoms and QT effects.
How serious is the interaction between Haloperidol and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased haloperidol adverse effects and consider a dose reduction if they appear, particularly when istradefylline 40 mg daily is used.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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