Drug interactions
Haloperidol + Lefamulin
Severity: Major
Haloperidol and Lefamulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is a CYP3A4 inhibitor and can raise haloperidol exposure, and both drugs can prolong the QT interval. The combination increases the risk of QT prolongation and torsades de pointes, particularly with oral lefamulin.
What this interaction means in plain words
Haloperidol and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Lefamulin belongs to Anti Bacterial.
Why it happens
Lefamulin inhibits CYP3A4-mediated haloperidol metabolism, with additive QT-prolonging effects.
What to do
Avoid the combination where possible and choose an alternative antibacterial. If it cannot be avoided, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Haloperidol with Lefamulin?
MediHelp rates the interaction as major. Haloperidol and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin is a CYP3A4 inhibitor and can raise haloperidol exposure, and both drugs can prolong the QT interval. The combination increases the risk of QT prolongation and torsades de pointes, particularly with oral lefamulin.
How serious is the interaction between Haloperidol and Lefamulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antibacterial. If it cannot be avoided, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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