Drug interactions
Haloperidol + Lumateperone
Severity: Moderate
Haloperidol and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are antipsychotics with dopamine D2 antagonism, so combining them adds to sedation, orthostatic hypotension and extrapyramidal effects without clear benefit. Haloperidol is at most a weak CYP3A4 inhibitor, so changes in lumateperone exposure are likely small.
What this interaction means in plain words
Haloperidol and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Lumateperone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic dopamine antagonism and CNS effects.
What to do
Avoid antipsychotic polypharmacy where possible; if combined, monitor for sedation, hypotension and extrapyramidal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Lumateperone
Frequently asked questions
Can I take Haloperidol with Lumateperone?
MediHelp rates the interaction as moderate. Haloperidol and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are antipsychotics with dopamine D2 antagonism, so combining them adds to sedation, orthostatic hypotension and extrapyramidal effects without clear benefit. Haloperidol is at most a weak CYP3A4 inhibitor, so changes in lumateperone exposure are likely small.
How serious is the interaction between Haloperidol and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible; if combined, monitor for sedation, hypotension and extrapyramidal symptoms.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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