Drug interactions
Haloperidol + Mavacamten
Severity: Minor
Haloperidol and Mavacamten: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared by CYP2C19 and CYP3A4, and haloperidol is at most a weak CYP3A4 inhibitor, so a significant exposure change is unlikely. Excess mavacamten exposure would risk reduced ejection fraction and heart failure.
What this interaction means in plain words
Haloperidol and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol.
What to do
Monitor left ventricular ejection fraction per mavacamten labeling and watch for heart failure symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Haloperidol with Mavacamten?
MediHelp rates the interaction as minor. Haloperidol and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mavacamten is cleared by CYP2C19 and CYP3A4, and haloperidol is at most a weak CYP3A4 inhibitor, so a significant exposure change is unlikely. Excess mavacamten exposure would risk reduced ejection fraction and heart failure.
How serious is the interaction between Haloperidol and Mavacamten?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction per mavacamten labeling and watch for heart failure symptoms.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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