Drug interactions
Haloperidol + Morphine
Severity: Moderate
Haloperidol and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol and morphine together can cause additive sedation, hypotension and respiratory depression. Haloperidol inhibits CYP2D6, but this has little impact on morphine, which is cleared mainly by glucuronidation.
What this interaction means in plain words
Haloperidol and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression; minor CYP2D6 inhibition by haloperidol is of limited relevance to morphine.
What to do
Monitor sedation, respiratory rate and blood pressure, particularly when doses are increased. Combination is commonly used in palliative care with titrated low doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Morphine?
MediHelp rates the interaction as moderate. Haloperidol and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol and morphine together can cause additive sedation, hypotension and respiratory depression. Haloperidol inhibits CYP2D6, but this has little impact on morphine, which is cleared mainly by glucuronidation.
How serious is the interaction between Haloperidol and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and blood pressure, particularly when doses are increased. Combination is commonly used in palliative care with titrated low doses.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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