Drug interactions
Haloperidol + Scopolamine
Severity: Moderate
Haloperidol and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol has weak anticholinergic activity, but with scopolamine the antimuscarinic and sedative effects can still add together, causing confusion, dry mouth, constipation and urinary retention. The combination is sometimes used deliberately in palliative care, so it is usually manageable.
What this interaction means in plain words
Haloperidol and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic blockade and CNS depression.
What to do
Monitor for delirium, sedation and urinary retention, particularly in older or frail patients, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Scopolamine?
MediHelp rates the interaction as moderate. Haloperidol and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol has weak anticholinergic activity, but with scopolamine the antimuscarinic and sedative effects can still add together, causing confusion, dry mouth, constipation and urinary retention. The combination is sometimes used deliberately in palliative care, so it is usually manageable.
How serious is the interaction between Haloperidol and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for delirium, sedation and urinary retention, particularly in older or frail patients, and use the lowest effective doses.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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