Drug interactions
Haloperidol + Suvorexant
Severity: Moderate
Haloperidol and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol has little clinically meaningful CYP3A4 inhibition, so a pharmacokinetic effect on suvorexant is unlikely to be large. The more relevant concern is additive sedation and next-day impairment.
What this interaction means in plain words
Haloperidol and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and antipsychotic sedative effects.
What to do
Start suvorexant at the lowest dose and warn about next-day drowsiness and impaired driving. Reduce the dose if excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Haloperidol with Suvorexant?
MediHelp rates the interaction as moderate. Haloperidol and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol has little clinically meaningful CYP3A4 inhibition, so a pharmacokinetic effect on suvorexant is unlikely to be large. The more relevant concern is additive sedation and next-day impairment.
How serious is the interaction between Haloperidol and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start suvorexant at the lowest dose and warn about next-day drowsiness and impaired driving. Reduce the dose if excess sedation occurs.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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