Drug interactions
Haloperidol + Tadalafil
Severity: Minor
Haloperidol and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is not a clinically significant CYP3A4 inhibitor, so no meaningful rise in tadalafil exposure is expected. Additive orthostatic hypotension from haloperidol's alpha-blocking effects is possible but modest.
What this interaction means in plain words
Haloperidol and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Tadalafil belongs to Genitourinary.
Why it happens
No established pharmacokinetic mechanism; slight additive hypotensive effects are possible.
What to do
No dose adjustment is needed; monitor for dizziness and orthostatic hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Tadalafil?
MediHelp rates the interaction as minor. Haloperidol and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Haloperidol is not a clinically significant CYP3A4 inhibitor, so no meaningful rise in tadalafil exposure is expected. Additive orthostatic hypotension from haloperidol's alpha-blocking effects is possible but modest.
How serious is the interaction between Haloperidol and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for dizziness and orthostatic hypotension.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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