Drug interactions
Haloperidol + Timolol
Severity: Moderate
Haloperidol and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a CYP2D6 substrate and inhibitor and may modestly raise timolol exposure. Both drugs can lower blood pressure, so hypotension or bradycardia may be more pronounced. The effect is usually modest.
What this interaction means in plain words
Haloperidol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
CYP2D6 inhibition by haloperidol plus additive hypotensive effects.
What to do
Monitor heart rate and blood pressure when starting or adjusting haloperidol. Reduce the timolol dose if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Timolol?
MediHelp rates the interaction as moderate. Haloperidol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is a CYP2D6 substrate and inhibitor and may modestly raise timolol exposure. Both drugs can lower blood pressure, so hypotension or bradycardia may be more pronounced. The effect is usually modest.
How serious is the interaction between Haloperidol and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or adjusting haloperidol. Reduce the timolol dose if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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