Drug interactions
Hemin + Heparin
Severity: Moderate
Hemin and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hemin can produce a transient coagulopathy with mild anticoagulant effects, possibly from its degradation product hematin. Together with heparin this may increase bleeding tendency.
What this interaction means in plain words
Hemin and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hemin belongs to Miscellaneous; Heparin belongs to Cardiovascular.
Why it happens
Hematin has mild anticoagulant and platelet-affecting activity that adds to heparin's effect.
What to do
Monitor aPTT and platelet count and watch for bleeding during hemin infusions in patients on heparin. Consider dose adjustment of heparin if coagulation is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
Frequently asked questions
Can I take Hemin with Heparin?
MediHelp rates the interaction as moderate. Hemin and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hemin can produce a transient coagulopathy with mild anticoagulant effects, possibly from its degradation product hematin. Together with heparin this may increase bleeding tendency.
How serious is the interaction between Hemin and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT and platelet count and watch for bleeding during hemin infusions in patients on heparin. Consider dose adjustment of heparin if coagulation is prolonged.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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