Drug interactions
Henbane + Risperidone
Severity: Moderate
Henbane and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains antimuscarinic alkaloids such as hyoscyamine and scopolamine that may add to risperidone's weak anticholinergic effects. This can cause confusion, constipation, urinary retention, tachycardia and delirium.
What this interaction means in plain words
Henbane and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Avoid henbane where possible because its alkaloid content is variable and it is toxic. If used, monitor for anticholinergic toxicity and cognitive changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Henbane with Risperidone?
MediHelp rates the interaction as moderate. Henbane and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains antimuscarinic alkaloids such as hyoscyamine and scopolamine that may add to risperidone's weak anticholinergic effects. This can cause confusion, constipation, urinary retention, tachycardia and delirium.
How serious is the interaction between Henbane and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid henbane where possible because its alkaloid content is variable and it is toxic. If used, monitor for anticholinergic toxicity and cognitive changes.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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