Drug interactions
Henbane + Tiotropium-olodaterol
Severity: Moderate
Henbane and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids, and can add to tiotropium's anticholinergic effects. This may cause dry mouth, tachycardia, urinary retention and confusion, and henbane has a narrow safety margin.
What this interaction means in plain words
Henbane and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic antagonism from plant tropane alkaloids.
What to do
Advise against henbane use with tiotropium. Monitor for anticholinergic toxicity if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Henbane with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Henbane and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids, and can add to tiotropium's anticholinergic effects. This may cause dry mouth, tachycardia, urinary retention and confusion, and henbane has a narrow safety margin.
How serious is the interaction between Henbane and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against henbane use with tiotropium. Monitor for anticholinergic toxicity if exposure occurs.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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