Drug interactions
Henbane + Trazodone
Severity: Moderate
Henbane and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains anticholinergic alkaloids such as hyoscyamine and scopolamine, and trazodone has mild anticholinergic and sedative properties. Together they may increase dry mouth, constipation, urinary retention, confusion and sedation.
What this interaction means in plain words
Henbane and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic and CNS depressant effects.
What to do
Avoid the herbal product, especially in older adults or those with glaucoma, urinary retention or cognitive impairment. Monitor for anticholinergic toxicity if use cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Henbane and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Henbane with Trazodone?
MediHelp rates the interaction as moderate. Henbane and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains anticholinergic alkaloids such as hyoscyamine and scopolamine, and trazodone has mild anticholinergic and sedative properties. Together they may increase dry mouth, constipation, urinary retention, confusion and sedation.
How serious is the interaction between Henbane and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the herbal product, especially in older adults or those with glaucoma, urinary retention or cognitive impairment. Monitor for anticholinergic toxicity if use cannot be avoided.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
