Drug interactions
Henbane + Trimipramine
Severity: Moderate
Henbane and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains antimuscarinic alkaloids such as hyoscyamine and scopolamine. With trimipramine they may cause additive anticholinergic effects, including confusion, tachycardia, urinary retention and constipation.
What this interaction means in plain words
Henbane and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Avoid the combination where possible, and monitor for anticholinergic toxicity if it is unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Henbane with Trimipramine?
MediHelp rates the interaction as moderate. Henbane and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains antimuscarinic alkaloids such as hyoscyamine and scopolamine. With trimipramine they may cause additive anticholinergic effects, including confusion, tachycardia, urinary retention and constipation.
How serious is the interaction between Henbane and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and monitor for anticholinergic toxicity if it is unavoidable.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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