Drug interactions
Heparin + Vortioxetine
Severity: Moderate
Heparin and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, like other serotonergic antidepressants, can impair platelet function and may increase bleeding tendency. With heparin the risk of bleeding, particularly gastrointestinal, may be somewhat higher.
What this interaction means in plain words
Heparin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake impairs platelet aggregation, adding to the anticoagulant effect of heparin.
What to do
Monitor for signs of bleeding such as bruising, melena or hematuria. Consider gastroprotection in patients with additional bleeding risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Heparin with Vortioxetine?
MediHelp rates the interaction as moderate. Heparin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine, like other serotonergic antidepressants, can impair platelet function and may increase bleeding tendency. With heparin the risk of bleeding, particularly gastrointestinal, may be somewhat higher.
How serious is the interaction between Heparin and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding such as bruising, melena or hematuria. Consider gastroprotection in patients with additional bleeding risk factors.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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