Drug interactions
Hepatitis a / b vaccine + Infliximab
Severity: Moderate
Hepatitis a / b vaccine and Infliximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combined hepatitis A/B vaccine is non-live and can be given with infliximab, but seroconversion rates and antibody titers may be lower, particularly for the hepatitis B component.
What this interaction means in plain words
Hepatitis a / b vaccine and Infliximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
TNF-alpha blockade attenuates B-cell and T-helper responses to vaccine antigens.
What to do
Vaccinate as indicated and check anti-HBs titers after the series, giving a booster or repeat series if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Hepatitis a / b vaccine with Infliximab?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Infliximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combined hepatitis A/B vaccine is non-live and can be given with infliximab, but seroconversion rates and antibody titers may be lower, particularly for the hepatitis B component.
How serious is the interaction between Hepatitis a / b vaccine and Infliximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated and check anti-HBs titers after the series, giving a booster or repeat series if the response is inadequate.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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