Drug interactions
Hepatitis a / b vaccine + Ocrelizumab
Severity: Moderate
Hepatitis a / b vaccine and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab-induced B-cell depletion blunts antibody responses to inactivated vaccines, so protection from the hepatitis A/B vaccine may be inadequate. The vaccine is not unsafe, but its effectiveness is reduced.
What this interaction means in plain words
Hepatitis a / b vaccine and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Depletion of CD20-positive B cells impairs humoral immune responses to vaccine antigens.
What to do
Complete vaccination at least 2 weeks before starting ocrelizumab where feasible. If given during treatment, check serology afterward and revaccinate as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Hepatitis a / b vaccine with Ocrelizumab?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab-induced B-cell depletion blunts antibody responses to inactivated vaccines, so protection from the hepatitis A/B vaccine may be inadequate. The vaccine is not unsafe, but its effectiveness is reduced.
How serious is the interaction between Hepatitis a / b vaccine and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete vaccination at least 2 weeks before starting ocrelizumab where feasible. If given during treatment, check serology afterward and revaccinate as needed.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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