Drug interactions
Hepatitis a / b vaccine + Temsirolimus
Severity: Moderate
Hepatitis a / b vaccine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus may impair seroconversion after this inactivated combined hepatitis vaccine. Patients may stay unprotected despite completing the series.
What this interaction means in plain words
Hepatitis a / b vaccine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses T- and B-cell responses needed for vaccine immunity.
What to do
Vaccinate before starting temsirolimus where possible. Check anti-HBs and anti-HAV titers after the series and revaccinate if inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Hepatitis a / b vaccine with Temsirolimus?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus may impair seroconversion after this inactivated combined hepatitis vaccine. Patients may stay unprotected despite completing the series.
How serious is the interaction between Hepatitis a / b vaccine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting temsirolimus where possible. Check anti-HBs and anti-HAV titers after the series and revaccinate if inadequate.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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