Drug interactions
Hepatitis a / typhoid vaccine + Temsirolimus
Severity: Moderate
Hepatitis a / typhoid vaccine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus may weaken the response to this inactivated combined vaccine, leaving the patient incompletely protected. No infection risk arises from the vaccine itself.
What this interaction means in plain words
Hepatitis a / typhoid vaccine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition reduces lymphocyte proliferation and so lowers vaccine immunogenicity.
What to do
Give before starting temsirolimus if travel allows. Otherwise vaccinate and consider checking hepatitis A antibody or repeating after therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Hepatitis a / typhoid vaccine with Temsirolimus?
MediHelp rates the interaction as moderate. Hepatitis a / typhoid vaccine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus may weaken the response to this inactivated combined vaccine, leaving the patient incompletely protected. No infection risk arises from the vaccine itself.
How serious is the interaction between Hepatitis a / typhoid vaccine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give before starting temsirolimus if travel allows. Otherwise vaccinate and consider checking hepatitis A antibody or repeating after therapy.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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