Drug interactions
Hepatitis b vaccine + Hydroxychloroquine
Severity: Minor
Hepatitis b vaccine and Hydroxychloroquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hepatitis B vaccine is non-live, and hydroxychloroquine is not known to meaningfully impair the immune response. Clinical impact is expected to be negligible.
What this interaction means in plain words
Hepatitis b vaccine and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mild immunomodulation may theoretically reduce antibody response; not well established.
What to do
Vaccinate according to schedule and check anti-HBs after the series where clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hepatitis b vaccine with Hydroxychloroquine?
MediHelp rates the interaction as minor. Hepatitis b vaccine and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hepatitis B vaccine is non-live, and hydroxychloroquine is not known to meaningfully impair the immune response. Clinical impact is expected to be negligible.
How serious is the interaction between Hepatitis b vaccine and Hydroxychloroquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to schedule and check anti-HBs after the series where clinically indicated.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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