Drug interactions
Hepatitis b vaccine + Ocrelizumab
Severity: Moderate
Hepatitis b vaccine and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab-induced B-cell depletion blunts antibody responses to inactivated vaccines, so hepatitis B vaccination may fail to produce protective titers. The vaccine remains safe, but its effectiveness is reduced.
What this interaction means in plain words
Hepatitis b vaccine and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Depletion of CD20-positive B cells impairs humoral immune responses to vaccine antigens.
What to do
Complete the vaccine series at least 2 weeks before starting ocrelizumab where feasible. If given during treatment, measure anti-HBs titers afterward and revaccinate if inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Hepatitis b vaccine with Ocrelizumab?
MediHelp rates the interaction as moderate. Hepatitis b vaccine and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab-induced B-cell depletion blunts antibody responses to inactivated vaccines, so hepatitis B vaccination may fail to produce protective titers. The vaccine remains safe, but its effectiveness is reduced.
How serious is the interaction between Hepatitis b vaccine and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the vaccine series at least 2 weeks before starting ocrelizumab where feasible. If given during treatment, measure anti-HBs titers afterward and revaccinate if inadequate.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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