Drug interactions
Histrelin + Ipratropium-salbutamol
Severity: Minor
Histrelin and Ipratropium-salbutamol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salbutamol can prolong the QT interval, particularly at high doses or with hypokalemia, and histrelin, like other GnRH agonists, may prolong QT through androgen deprivation. Combined use may modestly raise the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Histrelin and Ipratropium-salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Histrelin belongs to Musculoskeletal; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT-prolonging effects via beta-agonist-related hypokalemia and androgen deprivation.
What to do
No routine action is needed at usual doses; consider ECG and potassium checks in patients with other QT risk factors or heavy beta-agonist use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Histrelin and Ipratropium-salbutamol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ipratropium-salbutamol
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Ipratropium-salbutamol?
MediHelp rates the interaction as minor. Histrelin and Ipratropium-salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salbutamol can prolong the QT interval, particularly at high doses or with hypokalemia, and histrelin, like other GnRH agonists, may prolong QT through androgen deprivation. Combined use may modestly raise the risk of arrhythmia in susceptible patients.
How serious is the interaction between Histrelin and Ipratropium-salbutamol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed at usual doses; consider ECG and potassium checks in patients with other QT risk factors or heavy beta-agonist use.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
