Drug interactions
Histrelin + Lapatinib
Severity: Moderate
Histrelin and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with GnRH agonists such as histrelin can prolong the QT interval, and lapatinib has similar effects. Combined use may increase the risk of torsades de pointes.
What this interaction means in plain words
Histrelin and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Lapatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Obtain a baseline ECG and monitor ECG and electrolytes periodically, correcting potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Lapatinib?
MediHelp rates the interaction as moderate. Histrelin and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with GnRH agonists such as histrelin can prolong the QT interval, and lapatinib has similar effects. Combined use may increase the risk of torsades de pointes.
How serious is the interaction between Histrelin and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and electrolytes periodically, correcting potassium and magnesium abnormalities.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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