Drug interactions
Histrelin + Quinidine
Severity: Moderate
Histrelin and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist used for androgen deprivation, can prolong the QT interval through hormonal effects. Combined with quinidine, which prolongs QT strongly, this adds to the risk of torsades de pointes.
What this interaction means in plain words
Histrelin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with androgen deprivation from GnRH agonists contributing to repolarization changes.
What to do
Check a baseline ECG and electrolytes and repeat the ECG after starting. Consider an alternative to quinidine in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Quinidine?
MediHelp rates the interaction as moderate. Histrelin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist used for androgen deprivation, can prolong the QT interval through hormonal effects. Combined with quinidine, which prolongs QT strongly, this adds to the risk of torsades de pointes.
How serious is the interaction between Histrelin and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat the ECG after starting. Consider an alternative to quinidine in patients with other QT risk factors.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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