Drug interactions
Histrelin + Ziprasidone
Severity: Moderate
Histrelin and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can lengthen the QT interval through androgen deprivation. Combined with ziprasidone, it may add to the risk of QTc prolongation, though the effect is modest compared with direct channel blockers.
What this interaction means in plain words
Histrelin and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Androgen deprivation may prolong ventricular repolarization, adding to ziprasidone's direct QT effect.
What to do
Check baseline ECG and electrolytes, and repeat ECG after starting if other QT risk factors are present. Consider a lower-QT-risk antipsychotic in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Ziprasidone?
MediHelp rates the interaction as moderate. Histrelin and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can lengthen the QT interval through androgen deprivation. Combined with ziprasidone, it may add to the risk of QTc prolongation, though the effect is modest compared with direct channel blockers.
How serious is the interaction between Histrelin and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and repeat ECG after starting if other QT risk factors are present. Consider a lower-QT-risk antipsychotic in patients with cardiac risk factors.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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