Drug interactions
Human papillomavirus vaccine quadrivalent + Temsirolimus
Severity: Moderate
Human papillomavirus vaccine quadrivalent and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus-induced immunosuppression may blunt the antibody response to the HPV vaccine, leaving patients less protected. The vaccine is non-live, so there is no infection risk from the vaccine itself.
What this interaction means in plain words
Human papillomavirus vaccine quadrivalent and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression by mTOR inhibition reduces vaccine-induced immune responses.
What to do
Where possible, vaccinate before starting temsirolimus; otherwise give the vaccine when clinically needed and consider checking response or revaccinating after therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine quadrivalent with Temsirolimus?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine quadrivalent and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus-induced immunosuppression may blunt the antibody response to the HPV vaccine, leaving patients less protected. The vaccine is non-live, so there is no infection risk from the vaccine itself.
How serious is the interaction between Human papillomavirus vaccine quadrivalent and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate before starting temsirolimus; otherwise give the vaccine when clinically needed and consider checking response or revaccinating after therapy.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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