Drug interactions
Hyaluronidase + Hydroxyzine
Severity: Minor
Hyaluronidase and Hydroxyzine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Large systemic doses of antihistamines are reported to make tissues partly resistant to hyaluronidase, so the spreading effect may be reduced. Higher hyaluronidase amounts might be needed to achieve the desired dispersion.
What this interaction means in plain words
Hyaluronidase and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hyaluronidase belongs to Miscellaneous; Hydroxyzine belongs to Respiratory.
Why it happens
Antihistamines may reduce tissue responsiveness to hyaluronidase; the mechanism is not clearly defined.
What to do
Assess the dispersion effect and increase the hyaluronidase dose if the response is inadequate. No routine hydroxyzine adjustment is needed for typical doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Hyaluronidase with Hydroxyzine?
MediHelp rates the interaction as minor. Hyaluronidase and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Large systemic doses of antihistamines are reported to make tissues partly resistant to hyaluronidase, so the spreading effect may be reduced. Higher hyaluronidase amounts might be needed to achieve the desired dispersion.
How serious is the interaction between Hyaluronidase and Hydroxyzine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess the dispersion effect and increase the hyaluronidase dose if the response is inadequate. No routine hydroxyzine adjustment is needed for typical doses.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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