Drug interactions
Hydralazine + Iloprost
Severity: Moderate
Hydralazine and Iloprost: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure through vasodilation, so using them together can cause additive hypotension. This is most relevant during intravenous iloprost infusion, when blood pressure can fall quickly.
What this interaction means in plain words
Hydralazine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Iloprost belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation from iloprost (prostacyclin analogue) and hydralazine (direct arteriolar dilator).
What to do
Monitor blood pressure and heart rate closely during iloprost initiation and titration. Consider temporarily holding hydralazine during IV iloprost, and reduce the iloprost dose if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Hydralazine with Iloprost?
MediHelp rates the interaction as moderate. Hydralazine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure through vasodilation, so using them together can cause additive hypotension. This is most relevant during intravenous iloprost infusion, when blood pressure can fall quickly.
How serious is the interaction between Hydralazine and Iloprost?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely during iloprost initiation and titration. Consider temporarily holding hydralazine during IV iloprost, and reduce the iloprost dose if hypotension persists.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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