Drug interactions
Hydralazine + Labetalol
Severity: Moderate
Hydralazine and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both lower blood pressure, so combined use can produce additive hypotension. The pairing is often used deliberately, for example in hypertensive emergencies in pregnancy, and the beta-blocker also limits hydralazine-induced reflex tachycardia.
What this interaction means in plain words
Hydralazine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from alpha/beta-blockade and direct arteriolar vasodilation.
What to do
Monitor blood pressure and heart rate and titrate doses gradually. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Labetalol?
MediHelp rates the interaction as moderate. Hydralazine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both lower blood pressure, so combined use can produce additive hypotension. The pairing is often used deliberately, for example in hypertensive emergencies in pregnancy, and the beta-blocker also limits hydralazine-induced reflex tachycardia.
How serious is the interaction between Hydralazine and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate doses gradually. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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