Drug interactions
Hydralazine + Lornoxicam
Severity: Moderate
Hydralazine and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of antihypertensives, including hydralazine. The effect may be most noticeable with regular use.
What this interaction means in plain words
Hydralazine and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
Inhibition of vasodilatory prostaglandin synthesis with sodium and fluid retention.
What to do
Monitor blood pressure when NSAID therapy is started or used regularly. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Lornoxicam
Frequently asked questions
Can I take Hydralazine with Lornoxicam?
MediHelp rates the interaction as moderate. Hydralazine and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood pressure lowering effect of antihypertensives, including hydralazine. The effect may be most noticeable with regular use.
How serious is the interaction between Hydralazine and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when NSAID therapy is started or used regularly. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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