Drug interactions
Hydralazine + Methylphenidate
Severity: Moderate
Hydralazine and Methylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate can raise blood pressure and heart rate, which may reduce the effectiveness of hydralazine. Reflex tachycardia from hydralazine may add to this.
What this interaction means in plain words
Hydralazine and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Methylphenidate belongs to Central Nervous System.
Why it happens
Sympathomimetic reuptake blockade increases noradrenergic tone, opposing antihypertensive effects.
What to do
Monitor blood pressure and heart rate when starting or adjusting the stimulant. Increase antihypertensive therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Procarbazine Contraindicated
- Methylphenidate + Rasagiline Contraindicated
- Methylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Hydralazine with Methylphenidate?
MediHelp rates the interaction as moderate. Hydralazine and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylphenidate can raise blood pressure and heart rate, which may reduce the effectiveness of hydralazine. Reflex tachycardia from hydralazine may add to this.
How serious is the interaction between Hydralazine and Methylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting the stimulant. Increase antihypertensive therapy if needed.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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