Drug interactions
Hydralazine + Metoprolol
Severity: Minor
Hydralazine and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The drugs have additive blood pressure-lowering effects. Beta-blockers also blunt the reflex tachycardia caused by hydralazine, which is often a beneficial combination. Hydralazine may modestly increase metoprolol bioavailability.
What this interaction means in plain words
Hydralazine and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydralazine belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive vasodilation and beta-blockade; hydralazine may increase hepatic blood flow and reduce first-pass metabolism of metoprolol.
What to do
Monitor blood pressure and heart rate when starting or titrating either drug and adjust doses to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Metoprolol?
MediHelp rates the interaction as minor. Hydralazine and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The drugs have additive blood pressure-lowering effects. Beta-blockers also blunt the reflex tachycardia caused by hydralazine, which is often a beneficial combination. Hydralazine may modestly increase metoprolol bioavailability.
How serious is the interaction between Hydralazine and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating either drug and adjust doses to response.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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