Drug interactions
Hydralazine + Midazolam
Severity: Minor
Hydralazine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydralazine does not inhibit CYP3A4 in a clinically meaningful way, so no pharmacokinetic interaction with midazolam is expected. Both can lower blood pressure, but the effect is generally small.
What this interaction means in plain words
Hydralazine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydralazine belongs to Cardiovascular; Midazolam belongs to Central Nervous System.
Why it happens
No established pharmacokinetic mechanism; possible mild additive hypotension.
What to do
No dose change needed; monitor blood pressure during sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Midazolam?
MediHelp rates the interaction as minor. Hydralazine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydralazine does not inhibit CYP3A4 in a clinically meaningful way, so no pharmacokinetic interaction with midazolam is expected. Both can lower blood pressure, but the effect is generally small.
How serious is the interaction between Hydralazine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; monitor blood pressure during sedation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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