Drug interactions
Hydrochlorothiazide + Hydrochlorothiazide-olmesartan
Severity: Moderate
Hydrochlorothiazide and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains hydrochlorothiazide, so adding it separately duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hyperuricemia without added benefit.
What this interaction means in plain words
Hydrochlorothiazide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Therapeutic duplication leads to excess thiazide effect on renal sodium and potassium handling.
What to do
Avoid separate hydrochlorothiazide, and adjust the dose through the fixed-dose product or a different regimen. Monitor electrolytes and blood pressure if both have been taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains hydrochlorothiazide, so adding it separately duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hyperuricemia without added benefit.
How serious is the interaction between Hydrochlorothiazide and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid separate hydrochlorothiazide, and adjust the dose through the fixed-dose product or a different regimen. Monitor electrolytes and blood pressure if both have been taken.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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