Drug interactions
Hydrochlorothiazide + Indacaterol inhaled
Severity: Moderate
Hydrochlorothiazide and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a long-acting beta-2 agonist, can lower serum potassium, and thiazide diuretics also cause potassium loss. Concurrent use may increase hypokalemia and the risk of arrhythmias, especially with hypoxia or other risk factors.
What this interaction means in plain words
Hydrochlorothiazide and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 mediated intracellular potassium shift combines with thiazide renal potassium wasting.
What to do
Monitor serum potassium periodically, particularly at the start of therapy and in patients with severe COPD, and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a long-acting beta-2 agonist, can lower serum potassium, and thiazide diuretics also cause potassium loss. Concurrent use may increase hypokalemia and the risk of arrhythmias, especially with hypoxia or other risk factors.
How serious is the interaction between Hydrochlorothiazide and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, particularly at the start of therapy and in patients with severe COPD, and correct hypokalemia.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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