Drug interactions
Hydrochlorothiazide + Indapamide
Severity: Moderate
Hydrochlorothiazide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates therapy and adds to potassium, sodium and magnesium loss. The risk of hypokalemia, hyponatremia, dehydration and arrhythmia is increased with no meaningful added benefit.
What this interaction means in plain words
Hydrochlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Both drugs inhibit sodium-chloride reabsorption in the distal convoluted tubule, producing additive electrolyte loss.
What to do
Avoid using two thiazide-type diuretics together when possible. If combined, monitor serum electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide and Indapamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide
Other interactions of Indapamide
Frequently asked questions
Can I take Hydrochlorothiazide with Indapamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates therapy and adds to potassium, sodium and magnesium loss. The risk of hypokalemia, hyponatremia, dehydration and arrhythmia is increased with no meaningful added benefit.
How serious is the interaction between Hydrochlorothiazide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide-type diuretics together when possible. If combined, monitor serum electrolytes and renal function.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
