Drug interactions
Hydrochlorothiazide + Levosalbutamol
Severity: Moderate
Hydrochlorothiazide and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower serum potassium, so combined use can result in clinically significant hypokalemia, especially with high doses of levosalbutamol. This increases the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Hydrochlorothiazide and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Levosalbutamol belongs to Respiratory.
Why it happens
Beta-2 stimulation shifts potassium into cells, while thiazides increase renal potassium excretion.
What to do
Monitor serum potassium and replace it as required. Pay special attention to patients with cardiac disease or taking digoxin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Levosalbutamol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower serum potassium, so combined use can result in clinically significant hypokalemia, especially with high doses of levosalbutamol. This increases the risk of arrhythmia in susceptible patients.
How serious is the interaction between Hydrochlorothiazide and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and replace it as required. Pay special attention to patients with cardiac disease or taking digoxin.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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