Drug interactions
hydrochlorothiazide + lithium
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ lithium levels → toxicity.
Mechanism of action
↑ proximal reabsorption of lithium.
Clinical management
Avoid thiazides; if used, cut lithium dose and monitor.
Drug reference
References
Frequently asked questions
Can I take hydrochlorothiazide with lithium?
The interaction is rated: Major. ↑ lithium levels → toxicity.
How serious is the interaction between hydrochlorothiazide and lithium?
The interaction is rated: Major. Evidence level: High.
How is the interaction between hydrochlorothiazide and lithium managed?
Avoid thiazides; if used, cut lithium dose and monitor.
Why do hydrochlorothiazide and lithium interact?
↑ proximal reabsorption of lithium.
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